Based on the highest level of evidence available, the Pan American Health Organization's Clinical Practice Guidelines recommend that the first ROP screening test be performed according to a schedule that considers gestational age and the time of the first ROP screening. In all cases, newborns at risk of ROP should have at least one ROP screening before being discharged from the neonatal unit.
ROP screening is recommended for all newborns with a birth weight <2000 g and/or 36 weeks' GA or less, of any weight, who present at least one of the conditions identified as ROP risk factors.
The Guidelines recommend creating a ROP risk alert system in Neonatal Care Units that assesses gestational age, weight gain, and birth weight to determine ROP risk.
